Cover shows crystal structures of TGF-beta ligands and receptors. Clockwise from the top: TGF-beta2; BMP-7:ActRII; BMP-2:BRIA; Activin:ActRIIB; BMP-7:Noggin; Activin:ActRIIB; Activin:Follistatin; TGFbeta3: TbetaRII. Centre: putative signalling holo-complex consisting of TGF-beta ligand (blue and red) with two type I receptors (yellow) and two type II receptors (green). Courtesy of Teresa Woodruff and Jack Lin.
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