| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Summary. In litter-bearing mammals, the course of development of male and female fetuses is affected by the presence of other fetuses of the same or opposite sex located nearby within the uterus. The transport of testosterone between rat fetuses was examined by implanting a Silastic capsule containing [3H]testosterone into the amniotic sac of a fetus at either the ovarian or cervical end of a uterine horn on days 19 and 20 of pregnancy. The amount of testosterone that was recovered from the amniotic fluid of other fetuses 12 h later was determined. The amniotic fluid surrounding the adjacent fetus on the cervical side of the implanted fetus contained three times as much [3H]testosterone as did the adjacent fetus on the ovarian side, regardless of where in the uterus the implant was made. The movement of dye injected into the uterine lumen was towards the cervix. Intraluminal fluid movement may thus mediate the greater transport of [3H]testosterone towards the cervix than towards the ovary.
Our findings support the hypothesis that transport of testosterone between fetuses occurs across the fetal membranes via diffusion, such that any fetus (male or female) located between male fetuses receives the greatest supplement of testosterone.
Keywords: intrauterine position; intrauterine transport; sexual differentiation; rat
This article has been cited by other articles:
 |
|
 |
|
  K. M. Culbert, S. M. Breedlove, S. A. Burt, and K. L. Klump Prenatal Hormone Exposure and Risk for Eating Disorders: A Comparison of Opposite-Sex and Same-Sex Twins Arch Gen Psychiatry, March 1, 2008; 65(3): 329 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Khan, R. G Berger, and D. deCatanzaro The onset of puberty in female mice as reflected in urinary steroids and uterine/ovarian mass: interactions of exposure to males, phyto-oestrogen content of diet, and ano-genital distance Reproduction, January 1, 2008; 135(1): 99 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lapatto, J. C. Pallais, D. Zhang, Y.-M. Chan, A. Mahan, F. Cerrato, W. W. Le, G. E. Hoffman, and S. B. Seminara Kiss1 / Mice Exhibit More Variable Hypogonadism than Gpr54 / Mice Endocrinology, October 1, 2007; 148(10): 4927 - 4936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Shinwell, B. Reichman, L. Lerner-Geva, V. Boyko, I. Blickstein, and in collaboration with the Israel Neonatal Network "Masculinizing" Effect on Respiratory Morbidity in Girls From Unlike-Sex Preterm Twins: A Possible Transchorionic Paracrine Effect Pediatrics, September 1, 2007; 120(3): e447 - e453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. Barlow, S. L. Phillips, D. G. Wallace, M. Sar, K. W. Gaido, and P. M. D. Foster Quantitative Changes in Gene Expression in Fetal Rat Testes following Exposure to Di(n-butyl) Phthalate Toxicol. Sci., June 1, 2003; 73(2): 431 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Timms, R. E. Peterson, and F. S. vom Saal 2,3,7,8-Tetrachlorodibenzo-p-dioxin Interacts with Endogenous Estradiol to Disrupt Prostate Gland Morphogenesis in Male Rat Fetuses Toxicol. Sci., June 1, 2002; 67(2): 264 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rhen, E. Willingham, J. T. Sakata, and D. Crews Incubation Temperature Influences Sex-Steroid Levels in Juvenile Red-Eared Slider Turtles, Trachemys scripta, a Species with Temperature-Dependent Sex Determination Biol Reprod, November 1, 1999; 61(5): 1275 - 1280. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. S. v. Saal, B. G. Timms, M. M. Montano, P. Palanza, K. A. Thayer, S. C. Nagel, M. D. Dhar, V. K. Ganjam, S. Parmigiani, and W. V. Welshons Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses PNAS, March 4, 1997; 94(5): 2056 - 2061. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
