This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Koh, S. C. L. Articles by Ratnam, S. S. Search for Related Content PubMed Articles by Koh, S. C. L. Articles by Ratnam, S. S.

Concentration of plasminogen activators and inhibitor in the human endometrium at different phases of the menstrual cycle

Summary. The concentrations of tissue plasminogen activator (t-PA), urokinase plasminogen activator (u-PA) and plasminogen activator inhibitor (PAI-1) have been determined in endometrial curettings obtained from 46 subfertile women during proliferative, early or late secretory phases of the menstrual cycle. t-PA activity and antigen concentrations was significantly higher (P < 0·001) in late secretory endometrium than in proliferative or early secretory endometrium. Higher concentrations of PAI-1 antigen (P<·05) were also noted in late secretory phase than in proliferative and early secretory endometrium. However, u-PA concentration was not significantly different and no PAI activity could be demonstrated in the menstrual phases studied. Zymography studies confirmed the presence of both t-PA and u-PA in the endometrium. Ovarian hormonal patterns may therefore influence the activity of plasminogen activators especially of t-PA in the endometrium during various phases of the menstrual cycle.

Keywords: plasminogen activators; urokinase; plasminogen activator inhibitor; endometrium; human

This article has been cited by other articles:

				J. Nordengren, R. Pilka, V. Noskova, A. Ehinger, H. Domanski, C. Andersson, G. Hoyer-Hansen, S.R. Hansson, and B. Casslen Differential localization and expression of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitor (PAI-1) mRNA and protein in endometrial tissue during the menstrual cycle Mol. Hum. Reprod., September 1, 2004; 10(9): 655 - 663. [Abstract] [Full Text] [PDF]

				V. Jokimaa, S. Oksjoki, H. Kujari, E. Vuorio, and L. Anttila Expression patterns of cathepsins B, H, K, L and S in the human endometrium Mol. Hum. Reprod., January 1, 2001; 7(1): 73 - 78. [Abstract] [Full Text] [PDF]