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Androgenic regulation of enzymes involved in DNA synthesis in epididymis of young rats

Summary. In the epididymis of young rats, activities of DNA polymerases , β and and DNA topoisomerase I decreased after castration. DNA polymerase and increased with androgen administration and activity reached 81·3% and 78·0%, respectively, of the activity in the sham-operated group on day 21. Activity of DNA polymerase β remained at the activity of day 7 during androgen administration and was almost the same as that in the sham-operated group on day 21. DNA topoisomerase I activity showed a slight increase with androgen administration and reached 50·3% of that in the sham-operated group. The activities of these enzymes were not fully restored to those in the sham-operated group. These results indicate that in young rats activities of epididymal DNA polymerase and and DNA topoisomerase I are partially, and that of DNA polymerase β wholly, dependent on androgens and may provide a means of investigating the regulation of epididymal cell proliferation.

Keywords: DNA polymerases; DNA topoisomerase I; epididymis; castration; testosterone; rat

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