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Polypeptide growth factors in uterine tissues and secretions

AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT, U.K.

Keywords: growth factors; uterus; cell proliferation; blastocyst

Introduction: It has often been speculated that uterine secretions (histotrophe) are involved in regulating the attachment, implantation, nutrition and growth of the conceptus (Corner, 1921; Amoroso, 1952; Roberts & Bazer, 1988; Biggers, 1988). However, the factors responsible and the mechanisms involved have not been clearly defined. Work over the past decade has firmly established the involvement of peptide and polypeptide growth factors in the control of animal cell proliferation (see Evered et al., 1985). These results raise the intriguing possibility that uterus-derived growth factors may play a role in regulating the growth of the conceptus. This could occur via a paracrine pathway involving the secretion into the uterine lumen of factors which, on binding to specific cellular receptors, would directly stimulate DNA synthesis and division in cells of

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