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Cytogenetics of unfertilized human oocytes

Summary. During an in-vitro fertilization programme 150 oocytes from 62 women with a mean age of 31 years (range 24–39) remained unfertilized. Successful chromosome analysis was carried out on 96 oocytes by Q-banding: 59 (61·5%) oocytes bore a normal haploid complement, 8 (8·3%) were diploid and 3 (3·1%) tetraploid. In 26 (27·1%) oocytes aneuploidy was observed; these included 9 (9·4%) nullisomic, 5 (5·2%) double nullisomic, 4 (4·2%) triple nullisomic and 2 (2·1%) disomic oocytes. The remaining 54 (36·0%) oocytes could not be evaluated. A nearly uniform rate of aneuploidy was found for unfertilized oocytes among different donor age groups.

Keywords: chromosome study; human oocyte; in-vitro fertilization; aneuploidy

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