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The number of clonal precursors of the follicular epithelium in the mouse ovary

Summary. The number of clonal precursors of granulosa cells in mouse ovarian follicles has been estimated using a technique based on the phenomenon of random X-chromosome inactivation of somatic cells and the use of an X-linked alloenzyme variant of the glycolytic enzyme PGK-1. The granulosa cells of follicles were oligoclonal in origin and founded by a small number of cells (about 5) which was consistent with histological observations. When the analysis was extended to two subcompartments of the follicle, the mural and cumulus granulosa cells, the results indicated that the cumulus and mural granulosa cells had a common origin.

Keywords: granulosa cells; primordial follicles; phosphoglycerate kinase; ovary

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				P. G. Van Deerlin, N. Cekleniak, C. Coutifaris, J. Boyd, and J. F. Strauss III Evidence for the Oligoclonal Origin of the Granulosa Cell Population of the Mature Human Follicle J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3019 - 3024. [Abstract] [Full Text] [PDF]