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The milk oligosaccharide, lacto-N-fucopentaose I, inhibits attachment of mouse blastocysts on endometrial monolayers

Summary. Seven oligosaccharides isolated from human milk were tested for their effect in an in-vitro model of mouse blastocyst adhesion and trophoblast outgrowth on endometrial epithelial monolayers. One compound, lacto-N-fucopentaose I (LNF I), produced a significant reduction in the percentage of attached and outgrown blastocysts after co-culture for 72 h (P < 0·001). No significant effect of any other tested oligosaccharide was obtained.

Keywords: trophectoderm; uterine–epithelial cells; blastocyst; oligosaccharides; attachment; in vitro

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