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Effects of reciprocal ovary transplantation on reproductive performance of lethal yellow mice (A^y/a; C57BL/6J)

Summary. This study was conducted to determine whether reproductive failures in ageing, obese lethal yellow (A^y/a) females are due primarily to defects within A^y/a ovaries or to systemic defects which may operate outside the ovaries. Reciprocal ovary transplantation between control (a/a) and lethal yellow (A^y/a) females provided an experimental system to test the reproductive potential of not only A^y/a ovaries in control (a/a) females but also control (a/a) ovaries in mutant (A^y/a) females. Results on reproductive performance of all four combinations of grafts between A^y/a and a/a mice proved that A^y-induced reproductive failures are not due to intrinsic ovarian lesions but rather to defects operating extrinsically to the ovary. The hypothalamo–pituitary axis is a likely site for this reproductive lesion.

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