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A role for alternative pathway catecholamines in the regulation of steroidogenesis in cow luteal cells

Summary. Incubation of bovine luteal cells with the alternative pathway catecholamines octopamine, synephrine and deoxyadrenaline at concentrations of 10 ^–6 to 10^–3 M enhanced the production of progesterone (P < 0·05). Tryamine did not alter basal progesterone production (P > 0·05). Addition of noradrenaline and adrenaline at concentrations of 10^–4 to 10^–7 M significantly elevated the production of progesterone (P < 0·05). The steroidogenic response to noradrenaline and adrenaline was greater than that for octopamine, synephrine and deoxyadrenaline (P < 0·05). Response to both primary (10^–6 M) and alternative (10^–4 M) pathway catecholamines was inhibited by propranolol (10^–5M, P < 0·05) but not phentolamine (10^–5M, P > 0·05). These results demonstrate that octopamine, synephrine and deoxyadrenaline can affect steroidogenesis by bovine luteal cells, and their action is mediated by β-adrenergic receptors.