This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Louzan, P. Articles by Tramezzani, J. H. Search for Related Content PubMed Articles by Louzan, P. Articles by Tramezzani, J. H.

Gamma-aminobutyric acid in the genital tract of the rat during the oestrous cycle

Summary. The highest values of -aminobutyric acid (GABA) in the genital tract of the rat at different stages of the oestrous cycle were found in the oviduct (3·5–7 µg/mg protein) and the lowest in the ovary (50–100 ng/mg protein). The values for uterus and vagina ranged between 80 and 150 ng/mg protein. GABA (10–30 ng/µl was also found in fluid in the ovarian bursa. At 11:00 h, on the day of oestrus, GABA content increased in the ovaries but values in the oviducts were maximal at 11:00 h on the day of pro-oestrus. Variations in GABA content of the vagina were also found. Uterine cervix or uterine horn showed no changes during the oestrous cycle. The GABA content was not uniform throughout the oviduct: the highest values were found in the portion next to the ovary. At 10 days after removal of the right oviduct, GABA values in the ovary and ovarian bursa fluid decreased on the operated side. At 1 month after surgery, the values in ovary were normal but the values in ovarian bursa fluid were still low, suggesting that the source of ovarian GABA was not the oviduct. The variations observed in the present paper suggest an involvement of GABA in reproductive physiology.

This article has been cited by other articles:

				S. L. Petersen, S. Krishnan, and E. D. Hudgens The Aryl Hydrocarbon Receptor Pathway and Sexual Differentiation of Neuroendocrine Functions Endocrinology, June 1, 2006; 147(6): s33 - s42. [Abstract] [Full Text] [PDF]