This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Jahnsen, T. Articles by Hansson, V. Search for Related Content PubMed Articles by Jahnsen, T. Articles by Hansson, V.

Changes in germ cell adenylate cyclase and protein carboxyl methylase activities in rat testicular tissue during bilateral cryptorchidism and after orchidopexy

Summary. Soluble Mn²⁺-dependent adenylate cyclase and protein carboxyl methylase are two enzymes that are primarily localized in haploid germ cells of rat testicular tissue, and both enzymes exhibit an increase in activity in association with sexual maturation. Experimental cryptorchidism (surgery at 17 days of age) in immature rats prevented the age-dependent increase in the activity of these two testicular enzymes. After orchidopexy at 34 days of age the activities of these two enzymes increased to normal control values in association with testicular growth. These observations show that biochemical markers such as soluble Mn²⁺-dependent adenylate cyclase and protein carboxyl methylase can be used to follow germ cell differentiation.