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Cervical softening in late pregnant sheep by infusion of prostaglandin E-2 into a cervical artery

Summary. Cervical softening was induced in late pregnant sheep by infusion of PGE-2 into a cervical artery. The effect of this treatment was assessed by measurement of the extensibility in vitro of a strip of cervical tissue. After infusion of a saline/ethanol mixture extensibility was 2·84 x 10^–3 ± 0·3 x 10^–3 min^–1 (mean ± s.e.m., N = 5); after infusion of PGE-2 it increased significantly (P < 0·02) to 8·6 x 10^–3 ± 1·8 x 10^–3 min^–1 (N = 6). Infusion of PGE-2 did not increase uterine activity, and there was no significant change in the concentration of progesterone in the maternal jugular venous plasma. These data suggest that PGE-2 might act as a mediator of cervical softening in vivo and show that the cervix can soften in the absence of uterine contractions.

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