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Effect of gossypol on the motility and metabolism of human spermatozoa

Summary. Gossypol, a polycyclic compound isolated from cotton seeds, had a dose-dependent inhibitory effect on human sperm motility. The drug also inhibited powerfully fructolysis and glycolysis by human spermatozoa. Both lactate and CO₂ formation from the ¹⁴C-labelled sugars was inhibited, and the prevention of CO₂ formation from [1-¹⁴C]pyruvate and [2-¹⁴C]pyruvate by gossypol indicated a direct effect on the tricarboxylic acid cycle. Repeated washing of the sperm cells after gossypol pretreatment failed to abolish the inhibitory effect on CO₂ production. The profound disturbances of the sperm energy metabolism induced by gossypol were also reflected by a striking fall of the sperm ATP content. Gossypol had little effect on glucose utilization by minces of human vaginal mucosa, indicating the specificity of gossypol.

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				C.Y. Hong, J.J. Huang, and P. Wu The Inhibitory Effect of Gossypol on Human Sperm Motility: Relationship with Time, Temperature and Concentration Human and Experimental Toxicology, January 1, 1989; 8(1): 49 - 51. [Abstract] [PDF]