This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Popkin, R. M. Articles by Gosden, R. G. Search for Related Content PubMed Articles by Popkin, R. M. Articles by Gosden, R. G.

Effects of LH-RH agonist or LH-RH immunoneutralization on pituitary and ovarian LH-RH receptors in female rats

Summary. Hyperstimulation of pituitary function using daily injections of 50, 500 or 5000 ng LH-RH agonist for 3 weeks or hypostimulation by immunoneutralization of endogenous LH-RH led to disrupted oestrous cycles and profound changes in ovarian morphology. Despite this, the number of pituitary and ovarian LH-RH receptors remained within the range found in normally cyclic animals. Autoradiography confirmed that specific binding was located in theca, granulosa and luteal cells.

These results suggest that autoregulation of pituitary and ovarian LH-RH receptors is not of primary importance in the cyclic female rat.

This article has been cited by other articles:

				J. F. Couse, D. O. Bunch, J. Lindzey, D. W. Schomberg, and K. S. Korach Prevention of the Polycystic Ovarian Phenotype and Characterization of Ovulatory Capacity in the Estrogen Receptor-{alpha} Knockout Mouse Endocrinology, December 1, 1999; 140(12): 5855 - 5865. [Abstract] [Full Text]