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Effect of infusion of PGI-2, 6-keto-PGF-1 and PGF-2 on luteal function in the pregnant rat

Summary. Prostacyclin (PGI-2), 6-keto-PGF-1 and PGF-2 were infused continuously for 6 h into the dorsal aorta of rats 8 days pregnant. PGF-2 (10 µg/h) significantly reduced plasma progesterone concentrations by 66% and luteal tissue concentrations of pregnenolone and progesterone by 78% and 95% respectively. Plasma concentrations of 20-dihydroprogesterone remained unchanged whilst luteal tissue concentrations rose 2-fold. Plasma progesterone concentrations were significantly reduced to 50% by PGI-2 (10 µg/h) but were unaffected by 6-keto-PGF-1 (10 or 100 µg/h). Neither PGI-2 (10µg/h) nor 6-keto PGF-1 (10 or 100 µg/h) had any significant effect on plasma concentrations of 20-dihydroprogesterone or on luteal tissue concentrations of pregnenolone, progesterone or 20-dihydroprogesterone. Arterial blood pressure was unaffected by PGF-2 and 6-keto-PGF-1, but was significantly reduced by PGI-2 at infusion rates 60 µg/h.