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Retarded development of XO conceptuses during early pregnancy in the mouse

Summary. The growth and development of XO and XX mice were compared from 7 to 18 days of gestation. The 7-day XO egg cylinders were retarded in development (and consequently small) when compared with XX egg cylinders, and this lag in development remained until 10 days. By 12 days there was a considerable degree of 'catch-up', but this was not fully maintained. A subgroup of very severely retarded XO fetuses were preferentially located near the cervix. The placentas of XO fetuses were of normal size until 18 days when they were significantly larger than those of XX controls.

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