This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Milligan, S. R. Articles by Lytton, F. D. C. Search for Related Content PubMed Articles by Milligan, S. R. Articles by Lytton, F. D. C.

Changes in prostaglandin levels in the sensitized and non-sensitized uterus of the mouse after the intrauterine instillation of oil or saline

Summary. Intrauterine instillation of oil, but not saline, induced both a decidual cell reaction and a marked elevation in the uterine PGF- content of suitably sensitized ovariectomized mice. Uterine PGF- concentrations were elevated within 5 min of the oil instillation, reached maximal levels within 30–60 min and then declined to near baseline levels again by 3 h. A similar increase in uterine PGF- content in response to oil instillation was seen in non-sensitized females, although no decidual cell reaction developed. No significant changes in PGE or 6-oxo-PGF-1 content were observed. These results suggest that although the increase in uterine PGF- content is not solely due to the distension of the uterus after intrauterine injection, the increase is not necessarily sufficient to induce a decidual cell reaction.

This article has been cited by other articles:

				T. G Kennedy, C. Gillio-Meina, and S. H. Phang Prostaglandins and the initiation of blastocyst implantation and decidualization Reproduction, November 1, 2007; 134(5): 635 - 643. [Abstract] [Full Text] [PDF]