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Steroid hormones and embryo development in ovariectomized hamsters

Summary. Preimplantation embryo development was arrested at the premorula stage in hamsters ovariectomized on Day 1 of pregnancy. This effect was reversed when 500 µg progesterone were administered daily. Oestradiol-17β given alone had no significant effect on the cleavage rate or blastocyst formation, but a synergistic response was evident when a suboptimal (30 µg) dose of progesterone was given with 50 ng oestradiol-17β. Cholesterol and hydrocortisol had no effect on embryo development.