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Oestradiol-17β both inhibits and stimulates myometrial activity in ewes in vivo

Summary. Spontaneous intrauterine pressure cycles were abolished for periods of several hours in ovariectomized non-pregnant ewes within 8 h of an injection of 50 µg oestradiol-17β. Following the quiescent period, a phase of intense uterine activity ensued for several hours before again being replaced by several hours of quiescence. This active/inactive cycle disappeared after 2–4 days if further daily injections of oestradiol were not given. During the quiescent periods the uterus retained its responsiveness to oxytocin and PGF-2. Increasing the dose of oestradiol failed to prolong the periods of quiescence.