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Effect of oestradiol valerate on the rat blood–testis and blood–epididymal barriers to [³H]inulin

Summary. Micropuncture samples were taken from rats treated with 2·9 mg oestradiol valerate/day for 14 days, sham injected or untreated. Oestradiol valerate treatment reduced testicular weight and serum testosterone concentrations (P < 0·05), but did not alter the movement of [³H]inulin into seminiferous tubules or those of the cauda epididymidis. [³H]Inulin concentrations in the seminiferous tubule fluids were always <8% of blood isotope concentrations, and those in cauda epididymidal tubule fluid were always <5% of blood isotope concentrations. It was concluded that the maintenance of the anatomical component of the blood–testis and blood–epididymal barriers (cell–cell tight junctions) is not androgen-dependent.

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