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Chronic ethanol ingestion enhances GnRH-stimulated LH responses of castrated male dogs

Summary. Dogs were given no ethanol, 1·28 g ethanol/kg and 1·92 g ethanol/kg daily for 4 weeks immediately after castration. Plasma LH concentrations, basal and in response to 100 µg GnRH, were measured before and at 2 and 4 weeks after castration. Basal LH levels after castration increased significantly (P < 0·005) within each group but were not significantly different between groups. GnRH-stimulated LH responses were similar before and at 2 weeks after castration, but at 4 weeks the dogs given 1·92 g ethanol/kg had a significantly (P < 0·05) greater response than did the control dogs. It is concluded that daily ethanol ingestion in the amounts employed in this study does not impair hypothalamic–pituitary function in male dogs.