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Effects of 6-chloro-6-deoxysugars on glucose oxidation in rat spermatozoa

Summary. 6-Chloro-6-deoxyfructose or 6-chloro-6-deoxyglucitol (>90 µmol/kg/ day), 6-chloro-6-deoxyglucose or 6-chloro-6-deoxymannose (>120 µmol/kg/day) and 6-chloro-6-deoxygalactose (>300 µmol/kg/day) all had an antifertility action in the male rat when given by mouth. Spermatozoa from the infertile rats were unable to oxidize glucose. This effect was always produced by a lower dose than the antifertility effect and the threshold dose for the 2 effects varied in a parallel fashion between the different 6-chloro-6-deoxysugars. Glucose oxidation appeared to be inhibited at the triose phosphate isomerase or glyceraldehyde 3-phosphate dehydrogenase reaction. These effects of 6-chloro-6-deoxysugars are similar to those of -chlorohydrin.

The activities of the glycolytic enzymes were greatly in excess of the observed flux through the pathway and high concentrations of glucose 6-phosphate and triose phosphate accumulated in rat spermatozoa incubated with 2 mM-D-glucose.

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				W.C.L. Ford Glycolysis and sperm motility: does a spoonful of sugar help the flagellum go round? Hum. Reprod. Update, May 1, 2006; 12(3): 269 - 274. [Abstract] [Full Text] [PDF]