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Analysis of the LH surges induced by mating and LH-RH in the vole, Microtus agrestis

Summary. Female voles mated with a male and experiencing a single ejaculatory series exhibited a rapid and marked elevation of plasma LH levels. The profile of the LH surge had a broad peak 20–40 min after mating. Pentobarbitone sodium administered immediately after mating did not affect the magnitude of the surge. The LH response to exogenous LH-RH was not affected by the state of receptivity of the female or by gonadectomy. There was no evidence of any priming effect of 25 ng LH-RH on the pituitary response to a second injection of LH-RH 20 or 60 min later. These results are consistent with the primary cause of the LH surge in the reflexly ovulating vole being a rapid secretion of LH-RH.