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The failure of prolactin to enhance the inhibitory effect of oestradiol-17β on LH synthesis and release in ewes

Summary. Groups of 5–6 ovariectomized ewes were treated with oestradiol-17β (100 mg implant) and/or bromocriptine (1 mg; 2 x daily) or with vehicle for 30 days during the anoestrous season. Oestradiol increased (P < 0·05) the priming effect of 2 x 1 µg LH-RH on LH release and decreased (P < 0·001) pituitary LH content, plasma LH levels, the frequency and amplitude of pulsatile LH release and the LH response to LH-RH. Bromocriptine decreased prolactin levels to <2·5 ng/ml (P < 0·001) and increased the LH response to LH-RH (P < 0·05). There were no significant treatment interactions. It is concluded that prolactin does not enhance the inhibitory effect of oestradiol on LH synthesis and release in the ewe.