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Antiandrogenic effect of delta-9-tetrahydrocannabinol in adult castrated rats

Summary. In ventral prostate tissues of adult castrated rats, delta-9-tetrahydrocannabinol (THC) at 10 mg/kg for 7 days counteracted the testosterone-induced changes of (i) DNA, RNA and protein content, (ii) the tartrate-insensitive form of acid phosphatase, and (iii) the isoenzyme variant of acid phosphatase associated with the secretory type enzyme. These results indicate that THC acts anti-androgenically and directly at the level of male accessory sex organs.