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Immunoglobulin and complement receptor-bearing cells in cultures of mouse decidual tissue

Summary. Cells disaggregated from decidual tissue of the pregnant mouse were cultured overnight and examined in erythrocyte—antibody rosetting assays for the presence of cell surface receptors for the Fc region of immunoglobulin. Fc receptor-bearing cells were present from Day 4 post coitum (Day 1 = day of mating) as an increasing proportion of the total number of cells in the cultures, although the precise proportion showed considerable strain-dependent variation. In a similar assay, complement receptor-bearing cells were not detected in cultures of decidual tissue until 14–15 days of pregnancy. The presence of Fc receptor-bearing cells in the decidua supports the suggestion that this tissue may have a role in the immunological interactions between the mother and her antigenically alien embryo.