This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Adams, K. L. Articles by Roberts, R. M. Search for Related Content PubMed PubMed Citation Articles by Adams, K. L. Articles by Roberts, R. M.

Progesterone-induced secretion of a retinol-binding protein in the pig uterus

Summary. A retinol binding protein(s) of molecular weight about 17 000 has been demonstrated in uterine secretions from pigs in the luteal phase of the oestrous cycle. This protein was induced in ovariectomized sows treated with progesterone or progesterone plus oestradiol, but not in sows given oestradiol or corn oil. The vitamin A content of secretions from progesterone-treated animals also increased relative to those in controls. The apparent K_d of the binding protein for retinol was 2·6 x 10^–6 M. The protein had some affinity for retinoic acid and oleic acid, but did not bind retinyl esters or retinal. The protein probably comprises 5% or less of the total fraction of low molecular weight proteins induced by progesterone. A similar protein was found in allantoic fluid of pregnant animals, suggesting that, like uteroferrin, it serves to transport a water-insoluble nutrient from the maternal uterine endometrium to the conceptus.

This article has been cited by other articles:

				S Sukjumlong, A-M Dalin, L Sahlin, and E Persson Immunohistochemical studies on the progesterone receptor (PR) in the sow uterus during the oestrous cycle and in inseminated sows at oestrus and early pregnancy Reproduction, March 1, 2005; 129(3): 349 - 359. [Abstract] [Full Text] [PDF]

				J.L. Vallet and R.K. Christenson Effect of Progesterone, Mifepristone, and Estrogen Treatment During Early Pregnancy on Conceptus Development and Uterine Capacity in Swine Biol Reprod, January 1, 2004; 70(1): 92 - 98. [Abstract] [Full Text] [PDF]

				P. G. Groothuis, W. J. McGuire, J. L. Vallet, D. M. Grieger, and D. L. Davis Retinol and estradiol regulation of retinol binding protein and prostaglandin production by porcine uterine epithelial cells in vitro J Anim Sci, October 1, 2002; 80(10): 2688 - 2694. [Abstract] [Full Text] [PDF]

				F. J. Schweigert, K. Bonitz, C. Siegling, and I. Buchholz Distribution of Vitamin A, Retinol-Binding Protein, Cellular Retinoic Acid-Binding Protein I, and Retinoid X Receptor {beta} in the Porcine Uterus During Early Gestation Biol Reprod, October 1, 1999; 61(4): 906 - 911. [Abstract] [Full Text]

				J.L. Vallet, R.K. Christenson, and H.G. Klemcke Purification and Characterization of Intrauterine Folate-Binding Proteins from Swine Biol Reprod, July 1, 1998; 59(1): 176 - 181. [Abstract] [Full Text]