This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Aidara, D. Articles by Robyn, C. Search for Related Content PubMed PubMed Citation Articles by Aidara, D. Articles by Robyn, C.

Serum prolactin concentrations in mangabey (Cercocebus atys lunulatus) and patas (Erythrocebus patas) monkeys in response to stress, ketamine, TRH, sulpiride and levodopa

Summary. An homologous radioimmunoassay for human serum prolactin was validated to measure serum prolactin in 10 mangabey and 7 patas monkeys. Mean basal levels of serum prolactin were almost identical in the males of both species and in immature and mature males. However, basal levels were higher in females than in males.

Serum prolactin was enhanced by stress, i.v. injection of TRH and intramuscular injection of a potent dopamine antagonist (sulpiride). The rise in serum prolactin observed after i.m. injection of ketamine hydrochloride used as anaesthetic was of small amplitude and short duration. Oral administration of levodopa was followed by a significant fall in serum prolactin. Sexual maturity did not influence the responses to TRH or sulpiride. The mangabeys were more sensitive to sulpiride but less sensitive to levodopa than were the patas monkeys.

The variations in serum prolactin levels observed in these monkeys under the influence of stress, TRH, sulpiride and levodopa are similar to those observed in man to the same stimuli, although the experimental conditions were quite different.