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Hydroxysteroid dehydrogenases in the ovine endometrium and trophoblast

Summary. A histochemically demonstrable 3β-hydroxysteriod dehydrogenase appears in the uterine epithelium of the pregnant ewe on Day 12 and persists until after parturition. It is either very weak or absent in the non-pregnant ewe. A similar enzyme can just be seen in the trophoblast on Day 18, increases in strength until Day 33 and persists to term. The appearance of the endometrial enzyme coincides with events associated with maternal recognition of pregnancy.