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Uterine enzyme changes in thyroidectomized rats at parturition

Summary. Rats were thyroidectomized at different stages of gestation and killed at parturition. Acid phosphatase of uterine horns was significantly (P < 0·05) lower in animals thyroidectomized at later stages of pregnancy, whereas alkaline phosphatase was significantly lower in those thyroidectomized earlier as compared to intact pregnant animals. The activities of glutamic oxaloacetic acid and glutamic pyruvic acid transaminases also showed significant alterations in some of the thyroidectomized animals. These 4 enzymes were also studied in the cervix but the changes showed a less distinct pattern.