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The effect of intra-aortic prostaglandin F-2 on uterine motility in pregnant goats

Summary. Aortic infusions of PGF-2 to goats during late pregnancy had no dramatic effects on uterine motility. Only when plasma progesterone concentrations had decreased by 50% due to the luteolytic action of PGF-2 did uterine activity increase. No cervical softening was detected during the infusion periods. Cervical softening was detected after the decline in progesterone concentration and the increases in endogenous PGF and uterine motility. It is suggested that the corpus luteum, presumably by secretion of progesterone, has an inhibitory action on the cervix, preventing other hormones from inducing dilatation.

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				R. Smith Parturition N. Engl. J. Med., January 18, 2007; 356(3): 271 - 283. [Full Text] [PDF]