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Effect on fertility of female mice of the transfer of lymphocytes from females previously immunized with mouse spermatozoa

Summary. To examine the influence of cellular immunity to spermatozoa on the fertility of inbred mice, leucocytes were transferred from other female mice that had been immunized with spermatozoa. Both syngeneic and allogeneic systems were investigated. The cellular immune reaction was estimated using a footpad swelling test before and after the cell transfer. There was a significant increase of the paw thickness and a statistically significant reduction in fertility only for C3H mice immunized with C57BL spermatozoa.

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