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Onset of puberty and duration of fertility in rats fed a restricted diet

Summary. Chronic dietary restriction such that the body weight of CFY Sprague– Dawley female rats was 50% that of animals fed ad libitum resulted in enhanced longevity (LD₅₀ of 1090 days compared to 704 days). All the experimental females had reached puberty by 227 days and 80% were able to conceive and wean young at 510 days, an age beyond that at which the control rats had ceased to breed (450 days). Some (25%) of the experimental rats were able to breed at over 800 days of age.

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