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Target tissues for relaxin identified in vitro with ¹²⁵I-labelled porcine relaxin

Summary. Various tissues from the mouse, rat and guinea-pig were used to examine the binding of a biologically active, esterified and ¹²⁵I-labelled porcine relaxin. Binding to mouse symphysial homogenates was time- and temperature-dependent. Other peptide hormones did not compete with relaxin for binding. Mouse uterine tissue displayed similar binding characteristics. Fractionated mammary tissue from 15and 20-day-pregnant rats exhibited significant relaxin binding activity, as did homogenates of the guinea-pig pubic symphysis and cervix. Under the conditions used, no relaxin receptors were noted in the liver, spleen or heart from any of the species investigated.

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				R. A. Bathgate, R. Ivell, B. M. Sanborn, O. D. Sherwood, and R. J. Summers International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides. Pharmacol. Rev., March 1, 2006; 58(1): 7 - 31. [Abstract] [Full Text] [PDF]