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Fertility studies of complementing genotypes at the albino locus of the mouse

Summary. Mice doubly heterozygous for two radiation-induced lethal alleles at the albino locus (c^3H and c^6H) show partial complementation: they are viable but runted and sterile. In c^3H/c^6H females oogenesis and mating are normal, but nearly all of their fetuses, even when genotypically normal (+/c^3H or +/c^6H), fail to survive beyond midgestation. Abnormalities of spermatogenesis, i.e. morphological defects in head condensation and a deficiency in numbers of maturing spermatids, are histologically detectable in the testes of c^3H/c^6H males. Spermatozoa from the vasa deferentia of such males are predominantly nonviable, immotile, and grossly abnormal in morphology.

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