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Progesterone secretion by the corpus luteum of the early pregnant pig during superfusion in vitro with PGF-2, LH and oestradiol

Summary. Corpora lutea obtained from pregnant sows (Days 18–22) were superfused in vitro for 2—4 h with PGF-2 and for 3 h with LH or oestradiol or combinations of PGF-2 with LH or oestradiol. LH but not oestradiol stimulated progesterone secretion while superfusion for a minimum of 3 h with PGF-2 caused an irreversible decrease in progesterone secretion. LH and PGF-2 were mutually antagonistic while oestradiol did not inhibit the luteolytic action of PGF-2.