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Induction of avidin in the chick oviduct by tissue damage and prostaglandins

Summary. In immature, diethylstilboestrol-treated chicks, ligation of the oviduct caused local avidin synthesis in the immediate vicinity of the ligature. PGF-2 injected directly into the oviduct also induced avidin synthesis, whereas saline or PGE-2 had no effect. PGE and PGF-2 concentrations increased in the oviduct within 24 h of ligation: the PGE increase could be partly inhibited by indomethacin, whereas that of PGF-2 was less inhibited. An LD₅₀ dose of indomethacin alone and with ligation had a clear stimulatory effect on avidin synthesis, whereas aspirin alone, or with ligation, was not effective. Ligation alone and with indomethacin appeared to alter the PGF-2/PGE ratio. These results suggest that PGF-2 may be involved in the regulation of avidin synthesis in the chick oviduct.

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