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A priming effect of LH-RH on the pituitary in rams

In the female rat a single injection of LH-RH causes a rapid release of LH and primes the pituitary so that a further injection 1 h later produces a significantly increased response (Aiyer, Chiappa & Fink, 1974). A similar, although not so well pronounced, phenomenon occurs in ewes (Crighton & Foster, 1977) and women (Rommler & Hammerstein, 1974; Olivier & Faure, 1976; Wang, Lasley, Lein & Yen, 1976). Such a priming effect of LH-RH on LH has not been reported in male domestic animals; we therefore investigated the possibility in rams.