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Effects of an antioestrogen (MER-25) on sexual and mammary gland morphogenesis of the mouse fetus

The role of fetal androgens in the sexual and mammary differentiation of rodents has been investigated by many methods, including radio-destruction of the fetal testis (see Raynaud, 1969) and the administration of antiandrogens, especially cyproterone acetate (Elger & Neumann, 1966; Jost, 1972; Veyssière, Jean & Jean, 1974). Antioestrogens, however, have not been used in this type of study and we have therefore determined the effects of an antioestrogen (MER-25: Terenius & Ljungkvist, 1972) on the development of the genital and mammary anlagen of the mouse fetus.