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The effect of a single injection of mepivacaine hydrochloride on spermatogenesis in the rat

The purpose of this communication is to report that an intraperitoneal injection of a local anaesthetic, mepivacaine ((1-methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride), caused deleterious changes to the seminiferous epithelium of the rat testis. The effect of this reagent on spermatogenesis was studied because it is reported that it affects blood flow (Aberg & Wahlström, 1972) and it is well known that spermatogenesis is very sensitive to reduced blood flow (Cross & Silver, 1962).