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Inhibition by -chlorohydrin of fluid reabsorption in the rat cauda epididymidis

Daily injections of -chlorohydrin (3-chloro-1,2-propanediol) at a dose of 7–8 mg/kg produce infertility in male rats (Ericsson, 1970; Ericsson & Baker, 1970). The mechanism of action of this compound is still unknown but previous studies have indicated that it has at least two sites of action. When given at high doses, -chlorohydrin produces characteristic lesions in the caput epididymidis, leading to an occlusion of the epididymal duct and subsequent degeneration of the germinal epithelium (Ericsson, 1970; Hoffer, Hamilton & Fawcett, 1973; Cooper, Jones & Jackson, 1974). At lower doses, there is a functional interference with spermatozoa, causing a reversible phase of sterility (Coppola, 1969; Gunn, Gould & Anderson, 1969; Vickery, Erickson & Bennett, 1974), and the metabolism of testicular and epididymal spermatozoa is known to be affected (Mohri, Suter, Brown-Woodman, White & Ridley, 1975; Edwards, Dacheux & Waites, 1976).

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