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Fatty acid synthesis in human testis incubated with [1-¹⁴C]acetate

The lipid composition of human testes obtained at orchidectomy or at autopsy has been described (Coniglio, Grogan & Rhamy, 1974,1975), but it is not known whether these lipids have their origin in lipids transported by the blood and/or are synthesized by testicular tissue itself. The testicular synthesis of palmitic and stearic acids in vitro from [1-¹⁴C]acetate was demonstrated by Hall, Nishizawa & Eik-Nes (1963). Rat testicular tissue also has the ability to synthesize fatty acids de novo (Whorton & Coniglio, 1975) and to convert others into longer chains (Bridges & Coniglio, 1970a; Coniglio, Zseltvay & Whorton, 1971). Fatty acids synthesized by rat testes are incorporated into complex lipids of the testes (Evans, Zseltvay, Whorton & Coniglio, 1971).