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Effects of prostaglandins on ovarian blood flow in the bitch

Summary. Oestrous and anoestrous mongrel dogs were anaesthetized with chloralose–urethane. In one group, the ovaries were isolated in situ and the effects of a 15-min infusion of PGF-2 or PGE-2 on perfusion pressure were measured. In the other group, heated thermocouples were introduced into the stroma of each ovary to measure the changes of local blood flow in response to PGF-2 and PGE-2 infused into the ovarian bursa for 15 min. Intra-arterial infusion of 25,50,100 or 200ng PGF-2/kg/min did not affect perfusion pressure; PGE-2 doses of 3·1, 6·2, 12·5 or 25 ng/kg/min caused reductions in proportion to the dose. All doses of PGF-2 (50·0, 100or 200 ng/kg/min) or PGE-2 (25, 50 or 100 ng/kg/min) increased blood flow in the ovarian stroma in proportion to the dose when administered by infusion into the ovarian bursa. There were no differences in the results from oestrous and anoestrous dogs.

It is concluded that PGF-2 changes intraovarian blood distribution without interfering with the total blood flow while PGE-2 increases both the total and local ovarian blood flow.