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Normal and abnormal follicular growth in mouse, rat and human ovaries

We wish to present an analysis of the data gained by a group of workers studying various aspects of ovarian activity. Our work has been concerned primarily with two aspects of the development of follicles: the initiation and control of follicular growth, and differentiation and steroidogenesis in follicles approaching ovulation. The scope of our contributions spans the lifetime of the female from the early stages of growth in the fetal ovary to the final stages of follicular development in ageing females and includes both animal and clinical studies. The results are given in two main sections: follicular growth, and normal and abnormal differentiation and steroidogenesis in follicles approaching ovulation. Several aspects of follicular growth are considered in the discussion.

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