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Interrelations between plasma levels of biologically active LH and ovarian and adrenal steroids in the normal menstrual cycle

Almost exactly 30 years ago, in his classical book entitled The Hormones in Human Reproduction, George Corner (1947, p. 195) wrote the following: "After the excitement and the drama of the pioneer phase of research on the ovarian hormones, we are in for a lot of unspectacular measurement and computation, until the reactions of these substances in the body are quantitatively known as well as the chemist knows the reactions in his flasks." This paper is a review of such measurements and computations carried out during the past 5 years at the Reproductive Endocrinology Research Unit in Stockholm. It should be borne in mind that a large number of studies have been reported from other laboratories on the development of radioimmunoassays for pituitary, gonadal and adrenal steroids in systemic blood and those methods have been extensively applied to the study of the hormonal changes occurring during the menstrual cycle. No claims of the type 'first time in history' are made. If such aspects are of any importance at all, they can only be judged properly by the expert in the field. Hence, it is beyond the scope of the present paper to give a comprehensive critical review of the vast amount of literature accumulated on this subject or to cover the complex problem of hypotha-lamo-pituitary-ovarian relationships which is excellently reviewed by Yen (1977) in the preceding paper.