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Pituitary LH levels and response to LH-RH in female rats pretreated with oestradiol

The pituitary response to LH-RH can be modified by sex steroids (Debeljuk, Arimura & Schally, 1972a; Debeljuk, 1973; Debeljuk, Vilchez Martínez, Arimura & Schally, 1974) which can affect the gonadotrophin stores in the pituitary gland (McCann & Ramírez, 1964). It has been suggested, however, that an increased or decreased response to LH-RH is not necessarily correlated with an increase or decrease of pituitary gonadotrophin concentrations (Debeljuk, Arimura & Schally, 1972b; Debeljuk, Rozados, Daskal & Villegas Vélez, 1975). We therefore attempted to correlate changes in the pituitary response to LH-RH with pituitary LH concentrations in rats.