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Measurement of prostaglandins E and F in the uterine tissue and uterine fluid of ovariectomized rats treated with various doses of oestradiol-17β

There is now considerable evidence that prostaglandin (PG) F-2 of uterine origin is the luteolytic substance in several species (for reviews, see Weeks, 1972; Craig, 1975). Although the hormonal control of the synthesis and/or release of PGF-2 from uterine tissue is not fully understood, both oestrogen and progesterone may be involved. In the ovariectomized ewe PGF concentrations in the uterine tissue increase only when the animal is primed with progesterone and then treated with oestrogen (Caldwell, Tillson, Brock & Speroff, 1972). In the ovariectomized guinea-pig, however, PGF-2 synthesis can occur without prior treatment with progesterone (Naylor & Poyser, 1975). Although equivalent evidence is not available for other species, Lima, Gimeno, Goldraij, Benders & Gimeno (1971) found that treatment of ovariectomized rats with oestradiol-17β affected PGF-2 production only when used in small doses (i.e. 0·1 µg/day for 3 days); higher doses (i.e. 60 µg/day for 3 days) were ineffective. In the present investigation, the effects of various doses of oestradiol-17β on the yield of PGE and PGF from the uterine tissue and fluid of ovariectomized rats were further examined.