This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hopkinson, C. R. N. Articles by Hirschhäuser, C. Search for Related Content PubMed Articles by Hopkinson, C. R. N. Articles by Hirschhäuser, C.

Inhibin-like activity of bovine ovarian extracts in male and female rats

Several recent reports have confirmed the original postulate of McCullagh (1932) that the testis secretes a non-steroidal hormone which selectively inhibits pituitary FSH secretion. For example, extracts of bovine testis depress FSH levels in castrated male sheep (Lee, Keogh, de Kretser & Hudson, 1974) and FSH secretion in male rats is inhibited by human and bull seminal plasma (Franchimont, 1972; Franchimont, Chari, Hagelstein & Duraiswami, 1975). Inhibin activity has also been demonstrated in rete testis fluid (Setchell & Sirinathsinghji, 1972; Setchell & Jacks, 1974). Prompted in part by the fact that no known hormone is confined exclusively to one sex, we decided to test bovine ovarian extracts for inhibin-like activity. A preliminary account of this work has appeared (Hopkinson, Sturm, Daume, Fritze & Hirschhäuser, 1975).