This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hurst, P. R. Articles by Wheeler, A. G. Search for Related Content PubMed Articles by Hurst, P. R. Articles by Wheeler, A. G.

Intrauterine degeneration of embryos in IUD-bearing mice

The mouse uterus reacts to a unilateral intrauterine device (IUD) by developing partial-to-complete sterility in both the IUD- and contralateral horn (Doyle & Margolis, 1966; Marston & Kelly, 1969; Martin & Finn, 1970). Fertilization, tubal transport and development of embryos appear to be unaffected in such animals, but the numbers of embryos that can be recovered by flushing the uterus at the time at which they can be expected to have entered the horns are smaller than those recoverable from controls (Marston & Kelly, 1969; and our unpublished data). Flushing therefore does not distinguish between intrauterine death or premature expulsion of embryos from the mouse uterus. In an attempt to discover the fate of embryos in IUD-bearing mice the following histological experiment was undertaken.